The effect of disopyramide phosphate on ventricular fibrillation threshold of normal and ischemic ventricles.

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概要

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• The effect of disopyramide phosphate (DP) infusion (1mg/Kg and 2mg/Kg BW) on ventricular fibrillation threshold (VFT) was studied in anesthetized dogs. In the 1mg/Kg group, the VFT increased 47% above the control level immediately after infusion. In the 2mg/Kg group, a delayed increase in VFT was observed after the initial period and VFT was not correlated with the plasma concentration of DP. This phenomenon was abolished by pretreatment with methacholine. These results suggested an anticholinergic action of DP on the VFT. In the ischemic dogs produced by acute coronary occlusion, DP prevented a decrease in VFT.

• International Heart Journal刊行会の論文

著者

• TAJIMA Tsunemi

  Second Department of Internal Medicine, Saitama Medical School

関連論文

• Electrophysiologic Effects of Intravenous Adenosine Triphosphate Disodium on the Paroxysmal Supraventricular Tachycardias
• The effect of disopyramide phosphate on ventricular fibrillation threshold of normal and ischemic ventricles.

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