Ultrastructure and Mechanical Properties of Chordae Tendineae from a Myxomatous Tricuspid Valve

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概要

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• The ultrastructure and mechanical properties of chordae from a surgically removed myxomatous tricuspid valve were examined. Transmission and scanning electron microscopy showed the internal structure of the abnormal chordae to consist of a loose and relatively sparse network of disorganized collagen fibrils, with no well defined collagen bundles present. The abnormal tissue was found to be more extensible than normal and it ruptured at a stress that was only about 6% of the breaking stress for normal chordae. Chordal rupture, a common complication in this disorder, can be attributed to this decrease in chordal strength. At high strains, a decreased elastic modulus was also observed, which may be attributed to tissue changes and an alteration in collagen fibril structure and/or composition.

• International Heart Journal刊行会の論文

著者

• LIM Koon

  Department of Biophysics, Medicine, and Pathology, University of Western Ontario

• BOUGHNER Derek

  Department of Biophysics, Medicine, and Pathology, University of Western Ontario

• PERKINS D.

  Department of Biophysics, Medicine, and Pathology, University of Western Ontario

• Perkins D.Garth

  Department of Biophysics, Medicine, and Pathology, University of Western Ontario

関連論文

• Ultrastructure and Mechanical Properties of Chordae Tendineae from a Myxomatous Tricuspid Valve

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