The Spectrum of Double Outlet Right Ventricle Induced by Electrical Shocks to the Conotruncus of the Embryonic Chick : Implications of Tissue Dynamics
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概要
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Electrical shock stimulation of the conotruncal area induced a spectrum of double outlet right ventricle (DORV) in embryonic chicks at developmental stages 24-27. The device used to apply electrical potentials to the heart was constructed using a 9 battery, a push-button switch, and a 100ohm, ten-turn potentiometer with a calibrated dial. The potentiometer was connected as a voltage divider with the outlet connected to an electrode pair. This allowed for a short voltage pulse (variable 0 to 9) to be applied to a selected area of the heart through the electrodes. Two different methods were chosen to apply electrical shocks to the conotruncal area of the heart. One method utilized the application of an electrical shock between two points across the conotruncus of cardiac loop (horizontally oriented) and the second method between two points along the conotruncus of cardiac loop (vertically oriented).The range of voltages applied to the conotruncal area of the heart was from 2 to 4. Three distinct types of double outlet right ventricle were in the longitudinal (L) and horizontal (H) electrical shock groups:1) DORV without a ventricular septal defect (VSD), which is associated with a prolapse of an aortic valve into the right ventricle (5/50 cases in L group, 3/40 cases in H group).2) DORV with a subaortic VSD, with a variable degree of pulmonary stenosis and a hypoplastic left ventricle (20/50 cases in L group, 12/40 cases in H group).3) DORV with a subpulmonary VSD and a pulmonary stenosis, c hypoplastic right ventricle (15/50 cases in L group, 5/40 cases in H group).Longitudinal stimulation induced more cardiovascular anomalies than horizontal stimulation, and histological examination revealed the complete disappearance of the myocardial fibers, myocardial degeneration, and the aggregation of protein material or glycogen in the myocardial cells. The relationship between cell death processes in the conotruncal area and the DORV spectrum induced by electrical shock are discussed.
- International Heart Journal刊行会の論文
著者
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Masuda Hirotaka
Department of Obstetrics and Gynecology, School of Medicine, Keio University
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Takao Atsuyoshi
The Heart Institute, Tokyo Women's Medical College
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Okuyama Kazuo
Department of Pediatrics
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Takao Atsuyoshi
The Heart Inst. And Hosp.. Tokyo Women's Medical College Tokyo
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Masuda Hirotaka
Department Of Obstetrics And Gynecology Keio University School Of Medicine
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Ishikawa Shizen
Department Of Pediatrics Showa University
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NAGAO Masaaki
Department of Pediatrics, Showa University
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OKAWA Hideaki
Department of Pediatrics, Showa University
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GILBERT Enid
Department of Pediatrics & Pathology, University of Wisconsin
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TAKAO Atsuyoshi
The Heart Institute of Japan, Pediatric Cardiology, Tokyo Women's Medical College
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MASUDA Hirotaka
Department of Pediatrics, Showa University
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OKUYAMA Kazuo
Department of Pediatrics, Showa University
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GILBERT Enid
Department of Pediatrics & Pathology, University of Wisconsin
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