Enhancement of the Inotropic Action of Glucagon by Small Concentration of Angiotensin

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Under pentobarbital sodium anesthesia and bilateral vagotomy, studies were carried out in 2 groups of 3 dogs and another group of 4 and 7. Group 1 (4 dogs): Continuous i. v. infusion of angiotensin (5ng/Kg/10ml/min) produced no effects on LV contractility (LV dp/dt, maximum aortic flow velocity), LV stroke volume, heart rate or mean systemic BP. Group 2 (7 dogs): This concentration of angiotensin produced a greater increase in LVdp/dt following i. v. glucagon than those produced by glucagon alone. This potentiation with angiotensin, however, did not occur using epinephrine or isoproterenol, doses of which were chosen to provide a similar increase in LVdp/dt. Augmentation by angiotensin of chronotropic effects of these 3 drugs was not observed. Group 3 (3 dogs): Modification by angiotensin of inotropic effect of glucagon could be reproducible in propranolol pretreated dogs, and in 6 papillary muscle preparations (Group 4-3 dogs). The results suggest that small concentration of angiotensin (probably physiological level) may act on the cardiac contraction by indirect fashion.
International Heart Journal刊行会の論文