Influence of α- and β-Sympathetic Blockade on Hypoxic Sensitivity of the Coronaries
スポンサーリンク
概要
- 論文の詳細を見る
The effect of 2 types of adrenergic blockade on the capacity of the coronaries for hypoxic dilatation was studied in open chest dogs under chloralose anesthesia. Reactive hyperemia following the temporary occlusion of the left coronary artery and the vasodilatation elicited by general arterial hypoxia served to determine the range of coronary adaptation. β-adrenergic blockade induced by propranolol (0.3mg/Kg i.v. or 0.05mg/Kg intracoronarially) failed to reduce the range of hypoxic dilatation. On the other hand, the α-blocking agent phentolamine (0.45mg/Kg i.v. or 0.15mg/Kg i.c.), in association with a decrease of the vascular tone, significantly limited the coronary adaptation to hypoxia.
- International Heart Journal刊行会の論文
著者
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JUHÁSZ-Nagy Alexander
Department of Cardiovascular Surgery, Semmelweis University Medical School
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URBANICS Rudolph
Experimental Research Department
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JUHÁSZ-Nagy Alexander
Department of Cardiovascular Surgery, Semmelweis University Medical School