The Effect of Glucose Infusion on Myocardial Performance during Acute Hypoxia
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概要
- 論文の詳細を見る
The effects of hypoxia with or without glucose infusion on the cardiac contractility, blood pressure, electrocardiogram, blood electrolytes (sodium and potassium), glucose, pH, Po2, , and Pco2 in anesthetized dogs were studied. Hypoxia was induced by ventilating the dogs with reduced oxygen (10%) in the inspired air. Hypoxia produced a decrease in the cardiac contractility and blood pressure, and an increase in the heart rate and central venous pressure. It produced a decrease in the blood pH, Po2, and Pco2, and an increase in the blood glucose and potassium. Glucose infusion during hypoxia delayed the rate of decrease in the contractility and blood pressure significantly. The time for decrease in the contractility to 45 to 50% was increased by 67%. Glucose infusion prevented the loss of potassium from the cell. Glucose infusion however was unable to correct acidosis. These results indicate that glucose infusion during hypoxia might prevent or delay the deterioration of myocardial function.
- International Heart Journal刊行会の論文
著者
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PRASAD Kailash
Department of Physiology, College of Medicine, University of Saskatchewan
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LEWIS Gerald
Departments of Anaesthesia and Physiology, College of Medicine, University of Saskatchewan
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PRASAD Kailash
Department of Pharmacology and Thoracic and Cardiovascular Surgery, University Hospital, Faculty of Medicine, University of Alberta
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PRASAD Kailash
Departments of Anaesthesia and Physiology, College of Medicine, University of Saskatchewan
関連論文
- Cardiovascular Function in Experimental Chronic Mitral Insufficiency in Dogs
- The Effect of Glucose Infusion on Myocardial Performance during Acute Hypoxia
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