Treatment of Arteriosclerosis Vitamins and Sulfuric Esters of Polysaccharides

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概要

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Although the etiology of arteriosclerosis in man is extremely complicated and it is difficult to see the whole view of this field, I believe that my co-workers and I have studied on the etiology and treatment for arteriosclerosis particularly in relation to Vitamin B6 and lipemia clearing factor, and obtained favorable results in the prophylaxis of arteriosclerosis with dextran sulfate in relation to lipemia clearing factor. (1) Pyridoxal phosphate may be relating to lipemia clearing factor as a co-enzyme of it. (2) Vitamin B6 deficiency was produced in the Japanese monkey and marked arteriosclerotic pictures were seen in these monkeys. (3) Pyridoxal phosphate had the considerable effects on the treatment and particularly prophylaxis of experimental atherosclerosis in the rabbits fed lanolin. (4) Pyridoxal phosphate had favorable effects on the treatment of arteriosclerosis in man with the improvement of fat metabolism and clinical symptoms, although additional cases should be studied before any conclusion is drawn. (5) The dextran sulfate, which is low in the molecular weight and the sulphur content, is high in the clearing foctor activity, less toxic and very low in the anticoagulant activity. (6) This kind of dextran sulfate showed sufficient result in the prophylaxis of experimental atherosclerosis in rabbits. (7) This kind of dextran sulfate had a good influence on the lipid metabolism in aged person, although the method of administration should be further evaluated. (8) The dextran sulfate of low molecular weight is absorbed through the intestinal surface and it may be possible to improve the fat metabolism in aged person by the oral administration, too. Further study is needed in order to establish prophylaxis and treatment of arteriosclerosis in man.
International Heart Journal刊行会の論文

著者

Yamada K.
Third Department of Internal Medicine, Nagoya University School of Medicine

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