Changes of Brain Catecholamines in SHR following Bilateral Common Carotid Ligation

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概要

• 論文の詳細を見る

• It was demonstrated that the levels of brain CA were higher in SHR than NTR and that CA levels and turnover rates in SHR were changed during brain ischemia following BCL. Because of increase of DA in contrast to NA, brain ischemia in SHR may cause lowering activity of dopamine-β-hydroxylase rather than that of tyrosine hydroxylase. Futhermore, the fact that characteristic behaviors related to decreases of CA during ischemia, for example rolling, circling and jumping, occured after 3h of BCL and later in spite of increases of DA may probably reflect changes of DA receptors in SHR.Those results may he summarized that there are some abnormalities of brain CA system, including receptors, in SHR.

• International Heart Journal刊行会の論文

著者

• Shima Takeshi

  Depertment of Neurosurgery, Chugoku Rosai Hospital

• Shima Takeshi

  Depertment of Neurosurgery, Hiroshima university school of medicine

• Yoshida Hisanobu

  Medical chemistry, Hiroshima university school of medicine

• Nakajima Terumi

  Medical chemistry, Hiroshima university school of medicine

• Kajihara Shiro

  Depertment of Neurosurgery, Hiroshima university school of medicine

• Sokabe Takashi

  Depertment of Neurosurgery, Hiroshima university school of medicine

• Uozumi Tohru

  Depertment of Neurosurgery, Hiroshima university school of medicine

• Segawa Tomio

  Depertment of Pharmacology, Hiroshima university school of medicine

関連論文

• An Experimental Model of Cerebral Infarction Produced by Silicon Cylinder Embolization in Normotensive and Spontaneously Hypertensive Rats
• Changes of Brain Catecholamines in SHR following Bilateral Common Carotid Ligation

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