A Comparative Study on (Des-Aspartyl1)-Angiotensin II and Angiotensin II in Patients with Essential Hypertension
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概要
- 論文の詳細を見る
Twenty-one patients with essential hypertension received a constant infusion of angiotensin II and des-aspartyl1-angiotensin II for 45min on 2 consecutive days during normal sodium intake. Des-aspartyl1-angiotensin II increased mean blood pressure from 127.5±17.7 to 142.3±18.8mmHg and plasma aldosterone concentration from 12.1±7.8 to 18.8±11.4ng/100ml. Although plasma aldosterone concentration elevation was positively correlated with pre-infusion levels of plasma renin activity (r=0.862, p<0.001), mean blood pressure elevation was inversely correlated with the values of renin activity (r=-0.599, p<0.01). In contrast, elevations of both plasma aldosterone concentration and mean blood pressure were inversely correlated with pre-infusion levels of plasma renin activity in angiotensin II infusion. Des-aspartyl1-angiotensin II and angiotensin II were equally effective in suppressing renin release. These data demonstrate that des-aspartyl1-angiotensin II rather than angiotensin II plays an important role in aldosterone production in essential hypertension.
- International Heart Journal刊行会の論文
著者
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Mizuno Kenji
Third Department Of Internal Medicine Fukushima Medical College
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Fukuchi Soitsu
Third Department Of Internal Medicine Fukushima Medical College
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YAMAZAKI Masa-aki
Third Department of Internal Medicine, Fukushima Medical College
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