Pathological Background of the SER. Histological Findings in the Central Nervous System of the SER and Its Parentla Strains.:-Histological Findings in the Central Nervous System of the SER and Its Parental Strains-

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• The spontaneously epileptic rat (SER), a double mutant obtained by mating of the zitter and tremor rats, exhibits absence-like seizures and tonic convulsions without external stimulation from 7-8 weeks of age. These epileptic seizures are not observed in the parental strains except for absence-like seizures in the tremor rat. Histopathological studies of the central nervous system revealed the following abnormalities. The 35-day-old SERs which have never shown seizures had marked vacuole formation and hypomielination in the brainstem and cerebellum. The vacuoles were produced by splitting of myelin sheaths and swelling of dendrites and were related to primary swelling of the astrocytes. Ca<SUP>2+</SUP>-ATPase activity was low in all parts of the brain, particularly in the molecular layer of the cerebellum. All of the above mentioned changes were exactly similar to the changes observed in the tremor rats. The 2- to 3-month-old SERs with staggering gait and seizures showed focal axonal swelling and advanced vacuole formation in the granular cell layer of the cerebellum in addition to the abnormalities observed at 35 days. Degenerative neurons and spheroidal bodies were observed in the substantia nigra and ventral tegmental nucleus. Calcification of the neuropil was found in the midbrain. These structural abnormalities occurred with a combination of zitter and tremor phenotypes, and the brain areas showing the abnormalities are known to be related to tonic convulsions or absence-like seizures in the several models for epilepsy. Consequently, the SER is believed to be a useful tool for the investigation of the relationship between the morphological changes and epileptic seizures.

• 公益社団法人 日本実験動物学会の論文

公益社団法人 日本実験動物学会 | 論文

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