Substance Pの唾液分泌ならびにAmylase分泌作用の機作に関する研究--特に自律神経系とProstaglandins生合成との関連における

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概要

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• Salivary flow and amylase secretion induced by substance P(SP) administered intraventricularly were considerably less than that by SP given intravenously (i.v.). Salivary flow induced by SP (i.v.) was partially inhibited by baclofen, atropine, d-tubocurarine, alcuronium, phenylephrine and PGE<SUB>2</SUB>, while it was enhanced by arachidonic acid and indomethacin. Salivary amylase secretion induced by SP given i.v. was enhanced markedly by isoproterenol, phenoxybenzamine, phentolamine and No. 865-123 (an adrenergic neuron blocking agent), and moderately by baclofen, PGE<SUB>2</SUB> and arachidonic acid, while it was not influenced by propranolol. The enhancements of amylase secretion by adrenergic α-blockers were completely inhibited by propranolol. The <I>in vitro</I> examination using rat brain synaptosomes showed that SP promoted markedly the synthesis of PGs, especially of PGE<SUB>2</SUB>. These results suggest that the SP-receptor has a nicotinic receptor-like property and may be closely related to adrenergic α-receptors situated postsynaptically and presynaptically and to postsynaptic PGE<SUB>2</SUB>-receptors. From these results, it is concluded that SP-induced salivary flow and amylase secretion are modulated by the promotion of PGs synthesis in the autonomic nervous system.

• 社団法人 日本薬理学会の論文

著者

• 工藤 照夫

  大阪大学歯学部薬理学教室

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