モルモット輸精管に対するcatecholamineと強心配糖体の相互作用について

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概要

• 論文の詳細を見る

• The present study was undertaken in order to elucidate the site of drug interaction between digitalis and catecholamines. Experiments were designed to test the effect of digitalis glycoside on catecholamine-induced contraction of vas deferens isolated from guinea pig. Ouabain potentiated the catecholamine-induced contraction of vas deferens. Potentiation by interaction between ouabain and catecholamine was not produced following administration of phenoxybenzamine. In a potassium free medium, ouabain did not produce potentiation of the catecholamine-induced contraction. These results suggest that the interrelated potentiation between catecholamines and ouabain is at the site of the α-adrenergic recepter.

• 社団法人 日本薬理学会の論文

著者

• 尾谷 透

  北海道大学医学部薬理学教室

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