1-Ethyl-4-(2-morpholinoethyl)-3, 3-diphenyl-2-pyrrolinone hydrochloride (Doxapram) の薬理作用その1中枢作用について

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In the mouse, doxapram (DOP) given i. p. caused a pentylentetrazol-like convulsion and the ED50 was 131mg/kg i. p. Pretreatment with pentobarbital did not affect this value. In dogs, rabbits and rats anaesthetized with pentobarbital or urethane, a small dose of DOP (2mg/kg i. v.) caused facilitation of the phrenic nerve activity and a rise in blood pressure. The hypertension caused by administration of DOP was associated with increased spontaneous activity of the cervical sympathetic nerves. In vagotomized rats, dogs or rabbits, decentralized in depressor and sinus nerve, DOP had a slight effect on respiration. The pressor effect of DOP was inhibited by pretreatment with phentolamine or hexamethonium. The same phenomenon was also observed in reserpinized rats.
社団法人日本薬理学会の論文