Gas chromatography (GC) による脳内活性アミンの測定とその応用-第一部-

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概要

• 論文の詳細を見る

• During studies on the relationship between central biogenic amines and tolerance and physical dependence on morphine, we found that the widely used fluorometric assay for the estimation of brain amines has a number of defects. Some of these were high background values and lack of suitable controls for interfering substances in brain tissue. We therefore developed a set of new assays for the biogenic amines, dopamine, norepinephrine, 5-HT, 5-HIAA and acetylcholine. Using a system consisting of combined gas chromatograph mass spectrometer computeriz, these methods corrected several troublesome points in the fluorometric assays. Part 1 describes the gas chromatograph assays for dopamine, norepinephrine, 5-HT and 5-HIAA and its use to study the role of biogenic amines in physical dependence of mice on morphine.

• 社団法人 日本薬理学会の論文

著者

• 細谷 英吉

  慶応大学医学部

• 丸山 悠司

  Institute for Lipid Research, Baylor College of Medicine

• Takemori A.

  Department of Pharmacology, School of Medicine University of Minnesota

関連論文

• 〔VI〕麻薬の体内代謝について(シンポジウム麻薬に関する諸問題 : 特にモルヒネを中心として : 第20回日本薬学大会)
• Gas chromatography (GC) による脳内活性アミンの測定とその応用-第一部-
• A new assay method for the determination of choline and acetylcholine in brain by gaschromatography and mass spectrometry combination.

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