N-ethylmaleimide(NEM)の薬理学的能動性に関する研究-1-主としてモルモット交感神経シナプス機構におけるNEMの影響
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1) In isolated guinea-pig atria preparations, NEM was capable of producing not only elevation of contractile tension and increase in heart rates at earlier stages, but also elevation of resting tension with arrhythmia at later stages. All effects of NEM were, however, completely prevented if cysteine was added simultaneously and in equimolar concentration. 2) Effects of NEM at earlier stages were blocked by propranolol, guanethidine and reserpine, but restored by pre-incubation with norepinephrine in reserpinized atria. 3) At earlier stages, NEM enhanced the concentration of vas deferens induced by low frequency stimulation of the hypogastric nerve, but inhibited it at a later stage. 4) Enhancement by NEM of the contraction of vas deferens induced by sympathe-tic nerve stimulation appears to be dependent on Ca ion concentration in the suspending medium.