ChlorphentermineおよびSerotonin摂食抑制機構特にその作用点について
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概要
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Mechanism and site of action of chlorphentermine on the hypothalamic feeding center of the rat were investigated. Chlorphentermine is mose effective in depressing food intake in rats with ventromedial hypothalamic lesions compared with those in normal rats and less effective in rats with lateral hypothalamic lesions. The effect of chlorphentermine was decreased by pretreatment with tetrabenazine, a monoamine depleter. A single administration of 5-hydroxytryptophane (80mg/kg i. p.) depressed the food intake in normal rats. A microinjection of serotonin into the lateral part of the hypothalamus in normal rat produced a depression in food intake, while a microinjection of dopamine or noradrenaline produced facilitation. Results suggest that the action site of chlorphentermine could be the lateral part of the hypothalamus with serotonin possibly playing a role in the mechanism of action of chlorphentermine.
- 社団法人 日本薬理学会の論文