鹿茸抽出物pantocrinの効果 (実験的鞭打ち損傷の研究-2,3-)

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Physical, morphological and pharmacological studies of an experimental Whiplash Injury were done, using rabbits, to elucidate the injury mechanism and the effects of Pantui extracts, Pantocrin, on the injury. A device of rotary type, which is capable of producing concentrated exterior force effectively to the cervical region, was used to simulate experimental Whiplash Injury. The injured caput and cervical regions were physically, roentgenologically and pathologically examined and the requirement for producing Whiplash Injury of no serious damage was established, i.e., acceleration of 20G to the device and a weight of 300g an the rabbit head. In addition, a new method for optokinetic stimulation was employed to study nystagmus reactions on injured rabbits. Abnormally exaggerated patterns and lowered frequencies in the ENG were noted 3 to 21 days after the injury accompanying depressed glycolysis in cerebrospinal regions. Pantocrin, administered to the injured rabbits at an intramuscular dose of 1ml (ca. 1.5mg as a dry wt.) per kg daily from the 3rd to 21st day after injury, was markedly effective for improving the abnormalities in both ENG patterns and cerebrospinal glycolysis.
社団法人日本薬理学会の論文