Ethionine障害肝におよぼすMethionineならびにThioctic acidの影響

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概要

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• The influence of DL-Methionine and Thioctic acid on the experimentally injured liver in rabbits, were investigated. The injury was produced by subcutaneous injection of DL-Ethionine in daily dosage of 100mg/kg for three days. DL-Methionine and Thioctic acid were injected subcutaneously for six days before liver injury. Liver function tests, such as serum GOT, GPT, liver supernated GOT, GPT, and serum cholesterol were examined. Electronmicroscopical examination of the liver, were also performed. The observed findings were that DL-Methionine and Thioctic acid appeared to inhibit the liver injury to a certain degree, and that Thioctic acid appeared to be more effective than DL-Methionine.

• 社団法人 日本薬理学会の論文

著者

• 坂本 浩二

  東京医科大学薬理学教室

• 松島 美子

  東京医科大学薬理学教室

• 笠原 多嘉子

  東京医科大学薬理学教室

関連論文

• Ethionine障害肝におよぼすMethionineならびにThioctic acidの影響
• Pharmacological studies of liver damaging substance, ethionine:Part I; Bibliographic considerations of ethionine with reference to hepatic action
• Pharmacological studies of liver damaging substance, ethionine:Part II; Effects of ethionine on function and structure of the liver

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