恒常能障害ratにおけるACTH, Cortisoneの効果 : 脳のMAO活性値およびSerotonin量の変動について

概要

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The present study was undertaken to determine whether or not MAO activity and serotonin level in brain improves effect by adaptation hormones of homeotasis injured by formalin or reserpine injections. Male Wistar rats were subcutaneously injected with 5% formalin (8mg/kg) or 0.1% reserpine (1.25mg/kg) and or 0.2% ACTH (5mg/kg) or 2.5% cortisone (20mg/kg) every two days for 30 days. They were fed a high sucrose diet and 5% sucrose solution during this period. Animals were killed 16hr after last injections and MAO activity and serotonin content of whole brain were measured. Results are as follows. 1) Formalin, ACTH or cortisone induced hyperactivity of MAO, although each hormone combined with formalin induced no such activation. 2) There were no significant differences in the serotonin levels from brains after either treatment. 3) Reserpine induced hyperactivity of MAO and. such activation was furthermore provoked in the combination with cortisone but inhibited with ACTH. 4) Depletion of serotonin by reserpine was inhibited in combination with ACTH but not with cortisone. 5) Reserpine combined with formalin induced hypoactivity of MAO, however such combination did not influence the depletion of serotonin by reserpine.
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