新中枢性鎮痛薬1-(m-methoxy phenyl)-2-dimethyl-aminomethylcyclohexanol (1) HCl[CG-315]の代謝消長に関する研究

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概要

• 論文の詳細を見る

• 1) Subcutaneous administration of CG-315 to rats was followed by rapid absorption and distribution, especially highly in lung, spleen, liver, and kidney etc. Most of the injected drug was excreted in the urine within 24 hrs and a few in the feces. 2) Part of absorbed CG-315 may be mainly metabolized in liver to either O- or N-demethylated forms, some of which are conjugated with glucuronate. 3) No difference was found in metabolism of CG-315 between non-tolerant and tolerant rats.

• 社団法人 日本薬理学会の論文

著者

• 古田 博昭

  和歌山県立五稜病院内科

• 古田 博昭

  和歌山県立医科大学薬理学教室

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