1-Phenyl-1-hydroxy-n-pentaneのAmylase分泌促進効果の検定 : ラッテ膵臓摘出灌流標本およびイヌin situ標本による実験
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概要
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1. Intraduodenal administration of 1-phenyl-1-hydroxy-n-pentane (PHP) 200mg/kg body weight diluted with cocoanut oil produced significant increased in amount of amylase in the “flushed-out” solution. Intraduodenal administration of cocoanut oil 400mg/kg body weight failed to produce amylase secretion. 2. Perfusing the superior mesenteric artery with Tyrode solution containing PHP produced increase in amylase secretion in the isolated rat pancreas. The higher the concentration of the drug was given (ranging 0.5 to 2.5mg/ml) the larger amount of amylase was secreted. The enhancement of secretion due to PHP disappeared when calcium concentration in the perfusing solution was removed. 3. On these results, it is concluded that PHP acts on the pancreatic cells to secrete amylase. The mechanism of the action of PHP on the pancreas was discussed.
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