Capsaicinの循環器作用知見補遺慢性無線血圧犬における実験

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In the anesthetized dog, intravenously given capsaicin caused a transient apnoea, bradycardia and hypotension. Blood flows in the mesenteric, renal and femoral arteries were decreased, however, that of of carotid artery was increased even in a small dose causing no changes in the respiration, heart rate and blood pressure. Cardiac muscle contractility was depressed principally whilst capsaicin increased contractility of isolated guinea pig atrium. There were considerable shortening of apnoetic phase and complete vanishment of bradycardia after vagii cut. On the other hand, capsaicin caused a drastic increase of blood pressure and characteristic behavioral changes in the unanesthetized dog.
社団法人日本薬理学会の論文