Atropine様薬物の抗Muscarine作用と神経節遮断作用との比較

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The antimuscarinic and ganglion blocking activitities were compared in dogs, cats and the isolated guinea-pig ileums.<BR> The inhibitory effect of each drug on the gastric spontaneous motility and the salivation induced by the stimulation of the chorda tympani coincided with that on the hypotension induced by the stimulation of the vagus nerve respectively, but not with the acetylcholine-induced hypotension. These antimuscarinic activities of drugs in dogs were quite different from these ganglion blocking activity in cats. The relationship between the protective and lytic activities of drugs against acetylcholine-induced contraction in the isolated guinea-pig ileum corresponded with that against the hypotension induced by the acetylcholine administration and the vagus stimulation.
社団法人日本薬理学会の論文