Colistinおよびその誘導体によるHistamine様物質の遊離
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概要
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The effects of colistin salts and its derivatives, such as colistin sulfate (C-S), colistin tartrate (C-T), colistin pantothenate (C-P) and sodium colistin methanesulfonate (C-M), on the blood pressure in dogs were investigated and following results were obtained. Colistin salts caused marked and sustained fall in blood pressure. Among them, C-S showed the most marked effect. C-M showed very week effect compared with the others. Marked tachyphylaxis was seen on the depressor effect by the repeated administration.<BR> Histamine-like substances in blood in dog by the administration of colistin salts were quantified. The quantity of them was the most when it produced maximum fall in blood pressure. The effect of colistin salts on the blood pressure in rabbits was the same as that of histamine.
- 社団法人 日本薬理学会の論文