癌-間質相互作用を利用した癌の抑制
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概要
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Every organ or tissue is mainly composed of its characteristic epithelial cells and its stroma. Epithelial-stromal cell interaction between the epithelial cells and the surrounding stroma regulates growth and function of the highly differentiated epithelial cells and homeostasis of the tissue. Because characters of the epithelial cells and the stroma are different from each tissue, the epithelial-stromal cell interaction is specific to each tissue. Like normal tissue, solid tumor tissue is composed of tumor cells and surrounding stroma including fibroblasts, macrophages, and endothelial cells. Since most solid tumor is generated from epithelial cells, growth of the tumor cells is regulated by the surrounding stroma through diffusible factors and/or adhesion similar to normal tissue. This tumor-stromal cell interaction plays a significant role in tumor growth, invasion, and metastasis, but the molecular mechanisms underlying the interaction are still unclear due to its complexity. However, recent studies have revealed some basic backgrounds for the tumor-stromal cell interaction concerning specific tumor types. This review article has focused especially on fibroblasts among stroma and briefly summarized recent advance of the tumor-stromal cell interaction. The fibroblasts promote tumor growth in one condition, but they also suppress it in another condition. There is a chance to control the tumor growth by modulating the tumor-stromal cell interaction. The perspective for development of an antitumor drug that modulates the tumor-stromal cell interaction is also discussed.
- 日本DDS学会の論文
- 2003-07-10