Synthesis, Characterization and Biological Evaluation of Platinum(II) Complexes with a Chiral N-Monosubstituted 1,2-Cyclohexyldiamine Derivative

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概要

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• Eight platinum(II) compounds with a new chiral ligand, 2-(((1R,2R)-2-aminocyclohexylamino)methyl)phenol (HL), were designed, prepared and spectrally characterized. All compounds showed better aqueous solubility than cisplatin and oxaliplatin. In vitro cytotoxicity of these compounds against human HepG-2, MCF-7, A549 and HCT-116 cell lines was evaluated. Results indicated that all compounds showed cytotoxicity against A549 and HepG-2 cell lines. Particularly, compounds B1 and B8, which have CF3SO3− and (CH3)3COCH2COO− as leaving groups, respectively, exhibited better cytotoxicitiy than that of carboplatin in these two cell lines.

著者

• Xu Gang

  Jiangsu Province Hi-tech Key Lab. For Bio-medical Res. Southeast Univ.

• Gao Chuanzhu

  Pharmaceutical Research Center, School of Chemistry and Chemical Engineering, Southeast University

• Gou Shaohua

  Jiangsu Province Hi-Tech Key Laboratory for Bio-Medical Research, Southeast University

• Xu Gang

  Jiangsu Province Hi-Tech Key Laboratory for Bio-Medical Research, Southeast University

関連論文

• Synthesis, Characterization and Biological Evaluation of Platinum(II) Complexes with a Chiral N-Monosubstituted 1,2-Cyclohexyldiamine Derivative

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