Antioxidant Hispidin Derivatives from Medicinal Mushroom Inonotus hispidus

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概要

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• Two natural antioxidants, named inonotusin A (1) and B (2), were isolated from the methanolic extract of the fruit bodies of Inonotus hispidus, together with (E)-4-(3,4-dihydroxyphenyl)but-3-en-2-one (3), hispidin (4) and 3,4-dihydroxybenzaldehyde (5). Their structures were identified by means of extensive NMR and MS data analysis. Compounds 1, 2 and 4 exhibited significant scavenging activity against the 2,20-azinobis(3-ethylbenzhiazoline-6-sulfonate) (ABTS) radical cation. Compound 1 also showed moderate cytotoxicity against a human breast carcinoma cell line (MCF-7) with IC50 values of 19.6 μM.

• 公益社団法人　日本薬学会の論文

著者

• Zan Li-feng

  Engineering Research Centre of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural

• Qin Jian-chun

  College of Plant Sciences, Jilin University

• Zhang Ya-mei

  College of Plant Sciences, Jilin University

• Yao Yan-hua

  College of Plant Sciences, Jilin University

• Bao Hai-ying

  Engineering Research Centre of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural

• Li Xiang

  College of Plant Sciences, Jilin University

• Zan Li-feng

  Engineering Research Centre of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University

• Bao Hai-ying

  Engineering Research Centre of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University

関連論文

• Antioxidant Hispidin Derivatives from Medicinal Mushroom Inonotus hispidus

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