DDS with MFGM(milk fat globule membrame): intestinal absorption of MFGM-insulin emulsion.:intestinal absorption of MFGM-insulin emulsion

概要

論文の詳細を見る
A milk fat globule membrane (MFGM), which is the cell membrane derived from lactating mammary-gland cells, keeps fat globules stable in emulsion. The emulsifiability of MFGM is as strong as HCO60 and polysorbate 80, MFGM is expected to be a drug carrier. We have studied the intestinal absorption of MFGM-insulin emulsion in D. M. rats induced by streptozotocin. MFGM-insulin emulsion decreased blood glucose levels and increased serum insulin levels significantly. In the study of the intestinal lymphatic, MFGM-insulin emulsion significantly increased lymphatic insulin levels, as well. Compared with the lymph-borne and hematogenous absorption of insulin, the lymph-borne absorption was 3∼4 times more than the hematogenous absorption. These findings suggest that MFGM could be lymphotropic drug carrier on the oral administration.
日本DDS学会の論文