Effect of various vehicles on the ocular absorption of insulin in the albino rabbit.

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Effect of various vehicles on the ocular absorption of insulin was examined in the albino rabbits. The vehicles used in this study were 5% polyvinylalcohol(PVA), 0.1% polyacrylic acid (PAA), 0.2% hyaluronic acid (HA) and 1% Na-glycocholate was chosen as a model absorption promoter. Plasma glucose concentration was measured in a glucose analyzer whereas plasma insulin concentration was measured using radioimmunoassay. Of the vehicles, 0.1% PAA appeared to be more effective to enhance the ocular absorption of insulin than 5% PVA and 0.2% HA. The bioavailability of insulin from the ocular route without vehicle was about 1%, whereas in the presence of 0.1% PAA reached more than 5% based on both glucose and insulin measurements. Coadministration of 1% Na-glycocholate with 0.1% PAA tended to further hypoglycemic response and insulin absorption. The bioavailability of insulin with these additives was 13.6% based on glucose measurement and 7.4% based on insulin measurement. These findings indicated that it is feasible to obtain hypoglycemia from ocularly administered insulin with these additives.
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