Controlled release and permeation of mitomycin C from and through the gelatin films for implant.

概要

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Gelatin films and lipid dispersed gelatin films were prepared by various crosslinking and/or fixing conditions and their utility as an implant was estimated, In vitro degradation of the gelatin films in pH 7.4 phosphate buffer at 37°C was prolonged by increase in fixing. In vivo degradation period was 2-3 times longer than in vitro. In vitro mitomycin C (MMC) permeation profiles through these films were changed by fixing condition. The permeation rate of MMC through the films was delayed with increase in the amounts of fixing agent and lipid (soy bean oil and lethitin) in the film. In vitro MMC release from MMC suspended-gelatin film was also changed by the fixing condition. Based on these results, further in vitro release experiments were carried out by 2-and 3-layer films, prepared by several layers as above, where release rate of MMC from one side was designed to be much faster than that from the other side. As a result, observed data were consistent with calculated value. It was suggested that gelatin and lipid dispersed gelatin film were available as a dosage form for delivery of drug by desired release or permeation rate.
日本DDS学会の論文