エピネフリンと抗癌剤の腫瘍内投与による抗腫瘍効果の増強

概要

論文の詳細を見る
Modifing effect of epinephrine injected intratumorously (i.t) on the effect of anti-cancer drugs injected i.t was studied using Lewis lung carcinoma. Intratumoral injection of epinephrine (0.05 m<I>l</I>/tumor, 1.4 mg/kg) had no effect on tumor growth delay nor development of metastases. Intratumoral injection of epinephrine (0.028∼1.4 mg/kg) before intratumoral injection of anti-cancer drugs prolonged growth delay, as 2∼3 times in DWA2214R, (-)-(R)-2-aminomethylpyrrolidine (1, 1-cyclobutanedicarboxylato) platinum (II) monohydrate, and as 1.3∼1.4 times in peplomycin or mitomycin C as each drug alone, respectively. Low dose of epinephrine (0.014 mg/kg) enhanced the effect of DWA2114R as well as high dose. However, epinephrine reduced the effect of SMANCS, a derivative of neocarcinostatin conjugated with copolymer of styrene and meleic acid. The mechanism of enhancement effect was discussed. It was considered that epinephrine was useful in intratumoral injection of some drugs.
日本DDS学会の論文