Improvement of transfer of cisplatin to the parapulmonary lymph nodes by chemical modification with polyethyleneglycol.

概要

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Transfer of fluorescein isothiocyanate labeled dextrans(FD) to parapulmonary lymph nodes following intratracheal administration was investigated in rats, to clarify relationship between transfer of drug to parapulmonary lymphatic system and molecular weight. The concentrations of FD in parapulmonary lymph nodes increased with increasing molecular weight. For selective transfer of anticancer drugs to a parapulmonary lymphatic system, a macromolecular cisplatin(CDDP) derivative was synthesized by chemical modification with polyethyleneglycol, and the transfer of drug to the parapulmonary lymphatic system following intratracheal administration of the CDDP derivative was investigated. The concentrations of CDDP derivative in parapulmonary lymph nodes were much higher than that of CDDP. These findings suggested that chemical modification of CDDP with macromolecules is an effective approach for its selective transfer to parapulmonary lymphatic system.
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