Effect of Dietary Corticosterone and Vitamin E on Growth and Oxidative Stress in Broiler Chickens

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The present experiment was conducted to study the effects of dietary corticosterone (CTC) and vitamin E on growth and oxidative stress in broiler chickens. Chicks (Cobb strain) were divided into 3 (vitamin E)×2 (CTC) blocks. Vitamin E was mixed with basal diet at levels of 0 (EO), 500 (E500) and 5, 000 (E5000) mg DL α-tocopheryl acetate/kg. CTC was mixed with basal or vitamin E diets at a level of 20mg/kg. The body weight gain was significantly lower when the birds were treated with CTC. However, high dose vitamin E (5, 000mg/kg) reduced the CTC effect. Thus, the feed conversion ratio was higher in the CTC group and lower when vitamin E was given. CTC increased abdominal fat content and decreased adrenal glands weight, and vitamin E tended to reduce these effects. Thiobarbituric acid reactive substance (TBARS) in the liver was elevated by CTC, and it was significantly reduced by high dose vitamin E. The plasma cholesterol concentration was increased by CTC, and vitamin E reduced the effect. The plasma CTC concentration tended to be increased by CTC and this was further unexpectedly increased by vitamin E. In conclusion, the results indicate that CTC induces oxidative stress, hypercholesterolemia and growth inhibition, and these effects of CTC are minimized by vitamin E.
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