妊馬尿中の一結晶成分(Synstrone C)の雌マウスX-zoneに対する影響

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Synstrone C, which is a crystalline component separated from the non-estrogenic fraction of pregnant mare's urine by Komiya and Mochida, has been found to have an estrogen-promoting activity. Namiki and Mochida demonstrated that synstrone C (SC) injected simultaneously with stilbestrol showed an estrogen-promoting action in mature female mice. According to these investigators, SC is associated closely with the adrenal or pituitary gland.In the present work, SC was injected subcutaneously in 34 female mice of dd strain, which were examined for histological changes in X-zone cells. The mice were about 35 days of age, weighing 15 to 16, and were divided into two groups. Group A was treated with 0.5μg of SC daily for 12 days and group B with the same amount of 0.9% saline for the same period of time. In 78% of the mice of group A fatty metaplasia was induced, but no vacuolization was observed in them. In group B, only 19% of the animals showed metaplastic degeneration.On the other hand, some intact mice, weighing 17 to 18g, showed a marked fatty metaplasia similar to vacuolization. Therefore, more intensive study will be necessary to establish the action of SC promoting fatty metaplasia.
社団法人日本畜産学会の論文