クローズド・コロニー群として維持されているマウスの繁殖構造について
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With regard to the genetical control on maintenance of closed mice colony, a different method must be adopted other than that in inbred strains. That is, this method must aim at maintaining of genetical uniformity of the mice colony and prevention of occurrence of any subdivision in colony.ICR-JCL mice colony as multiple purpose mice in a closed colony has been maintained by the" mating system of rotation for non-inbred" in three groups and this colony has about 240 males and 1, 440 females in each generation.In order to investigate on breeding structure of this mice colony, the estimation was made in i) number of progenies during lifetime, ii)the effective population size and iii) coefficient of inbreeding and index of subdivision.i) The pattern of distribution of the number of progenies contributed by parents during lifetime showed fairly good fitness to normal distribution. The mean number of progenies during lifetime were 234 in male parents and 40 in females, but the great part of them would be used for experimental mice. The type of distribution of progenies used for breeding on next generation showed fitness to log-normal distribution(see Fig. 3-4). The mean nuber of progenies used for breeding were 9.6 in male parents and 5.7 in females.ii) The effective population size was estimated by the formula: N=2(N'm+N'f){2(N'm+N'f)-1}/Nmσ2km+Nfσ2kf+2(_??_m+_??_f-1)(N'm+N'f)-Nm_??_2m-Nf_??_2f in which Nm and Nf being the number of male and female parents contributed progenies to next generation, _??_m, _??_f and σkm, σkf: means and standard deviations of progenies who were contributed by members of parents, and N'm and N'f: the number of progenies used for breeding on next generation. The effective population size of this colony was estimated as abou 370 (see Table 1). The, the rate (K) of random fixation of gene per generation may be 0.14%.iii) The total inbreeding coefficient (F) and that (F') contributed from inter-se relation- ship (R) were estimated by using WRIGHT and MCPHEE's method. The total inbreeding coefficient was 0.828%. It is about two and a half years and 5.8 generations since their laboratories started to breed this colony, then, the inbreeding coeficient was increased about 0.14% per generation. The inbreeding contributed from inter-se relationship was 0.959%. The index of subdivision (F/F')was estimated as 0.86.These facts may show that this colony has been maintained under the condition to prevent inbreeding and occurrence of subdivision.
- 社団法人 日本畜産学会の論文
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- クローズド・コロニー群として維持されているマウスの繁殖構造について