Functional Transformation of Gastric Parietal Cells and Intracellular Trafficking of Ion Channels/Transporters in the Apical Canalicular Membrane Associated with Acid Secretion
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概要
- 論文の詳細を見る
The parietal cell of the gastric gland is a highly differentiated cell responsible for the gastric hydrochloric acid secretion into the lumen of the stomach. In response to stimulation of acid secretion, the parietal cells undergo well-characterized morphological transformations to recruit H+/K+-ATPase from the cytoplasmic tubulovesicles to the apical canalicular membrane. Besides H+ extrusion via H+/K+-ATPase, Cl− efflux and K+ recycling across the apical canalicular membrane are necessary via chloride and potassium channels/transporters, respectively. In the last decade, a number of molecular candidates for the Cl− efflux and K+ recycling have been identified in the apical canalicular membrane of the parietal cell. This review focuses on the functional transformation of gastric parietal cells and intracellular trafficking of ion channels/transporters expressed in the apical canalicular membrane associated with gastric acid secretion.
- 公益社団法人 日本薬学会の論文
著者
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SAWAGUCHI Akira
Department of Anatomy, Ultrastructural Cell Biology, Faculty of Medicine, University of Miyazaki
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Aoyama Fumiyo
Department Of Anatomy Ultrastructural Cell Biology Faculty Of Medicine University Of Miyazaki
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Sawaguchi Akira
Department Of Anatomy Ultrastructural Cell Biology Faculty Of Medicine University Of Miyazaki
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