Characterization of 2-Octenoyl-CoA Carboxylase/Reductase Utilizing pteB from Streptomyce avermitilis
スポンサーリンク
概要
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The filipin biosynthetic gene cluster of Streptomyces avermitilis contains pteB, a homolog of crotonyl-CoA carboxylase/reductase. PteB was predicted to be 2-octenoyl-CoA carboxylase/reductase, supplying hexylmalonyl-CoA to filipin biosynthesis. Recombinant PteB displayed selective reductase activity toward 2-octenoyl-CoA while generating a broad range of alkylmalonyl-CoAs in the presence of bicarbonate.
著者
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YOO Hye-Gyeong
Department of Biological Science, Division of Bioscience and Bioinformatics, Myongji University
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KWON So-Yeon
Department of Biological Science, Division of Bioscience and Bioinformatics, Myongji University
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KIM Suji
Department of Biological Science, Division of Bioscience and Bioinformatics, Myongji University
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KARKI Suman
Department of Biological Science, Division of Bioscience and Bioinformatics, Myongji University
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PARK Zee-Yong
Department of Life Sciences, Gwangju Institute of Science and Technology
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KWON Hyung-Jin
Department of Biological Science, Division of Bioscience and Bioinformatics, Myongji University
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Park Zee-yong
Department Of Life Sciences Gwangju Institute Of Science And Technology
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Kwon Hyung-jin
Department Of Biological Science Division Of Bioscience And Bioinformatics Myongji University
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Yoo Hye-gyeong
Department Of Biological Science Division Of Bioscience And Bioinformatics Myongji University
関連論文
- Characterization of 2-Octenoyl-CoA Carboxylase/Reductase Utilizing pteB from Streptomyce avermitilis
- Characterization of 2-Octenoyl-CoA Carboxylase/Reductase Utilizing pteB from Streptomyce avermitilis