ABC Transporters Involved in the Biogenesis of the Outer Membrane in Gram-Negative Bacteria

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概要

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• The outer membrane of gram-negative bacteria is an asymmetric lipid bilayer with phospholipids and lipopolysaccharides (LPSs). β-Barreled outer membrane proteins and lipoproteins are embedded in the outer membrane. All of these constituents are essential to the function of the outer membrane. The transport systems for lipoproteins have been characterized in detail. An ATP-binding cassette (ABC) transporter, LolCDE, initiates sorting by mediating the detachment of lipoproteins from the inner membrane to form a water-soluble lipoprotein-LolA complex in the periplasm. Lipoproteins are then transferred to LolB at the outer membrane and are incorporated into the lipid bilayer. A model analogous to the Lol system has been suggested for the transport of LPS, where an ABC transporter, LptBFG, mediates the detachment of LPS from the inner membrane. Recent developments in the functional characterization of ABC transporters involved in the biogenesis of the outer membrane in gram-negative bacteria are discussed.

著者

• Narita Shin-ichiro

  Institute Of Electronics Shizuoka University

関連論文

• A New Screening Method to Identify Inhibitors of the Lol (Localization of lipoproteins) System, a Novel Antibacterial Target
• Photo-Hall Effect of Zinc Sulfide Crystals
• ABC Transporters Involved in the Biogenesis of the Outer Membrane in Gram-Negative Bacteria
• Membrane Topology and Functional Importance of the Periplasmic Region of ABC Transporter LolCDE
• Electroluminescence in Zinc Sulfide Single Crystals

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