細胞の表層荷電と表層構造 : 細胞電気泳動法を中心として

概要

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Recent progress in cell biology is demonstrating that the plasma membrance plays the important roles responsible for the growth and the differentiation of animal cells, as a mediator of cell-to-cell interaction. Cell electrophoresis is one of the methods of characterizing the cell surface with a minimal of external influence.<BR>The charge pattern of the cell surface reflects ionogenic groups at glycocalix or cell coat, a carbohydrate-rich layer, which locates the most peripheral region of plasma membrane. Changes which have been produced in the cell electrophoretic mobility by biophysical and biochemical means permit deductions about the nature of membrane structures. The ionogenic substances at the cell surface are sialic acid, mucopolysaccharides, lipids, RNA and proteins. These substances on the cell surface was discussed in connection with cell growth and differentation.
日本生物物理学会の論文