神経細胞のシナプス後電位
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概要
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Postsynaptic potentials of the protrusive and retractive motoneurons (P-Mn and R-Mn) in the hypoglossal motor nucleus evoked by stimulation of the bilateral lingual nerves (ipsi-L and contra-L) were explored in anesthetized cat. IPSPs in the Type B neurons of both the P-Mn and R-Mn were composed of the fast and slow IPSPs. Strychnine blocked the fast IPSP but slow IPSP was resistant to the drug. When Cl ions injected into the Mn the fast IPSP was reversed, but the slow IPSP was not. Passing the HP currents across the membrane the fast IPSP reversed to the depolarizing potentials, however, there was no changes in the slow IPSP.<BR>It was found that the ipsi-L mainly connected on the R-Mn with the synapse related to the fast IPSP, but the contra-L mainly with the synapse of the slow IPSP. From the changes of a ratio of the slow IPSP to the fast IPSP in axotomized Mns, it is suggested that the inhibitory synapses related to the slow IPSP become to diminish their effectiveness after axotomy.
- 日本生物物理学会の論文