赤血球膜の糖輸送と浸透圧挙動

概要

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Sugar transport across erythrocyte membrane has been studied by many investigators. Analysis of the Michaelis-Menten kinetics has been applied to the sugar transport since Widdas formulated the carrier mediated transport model. However, many different values of Km and Vmax Were reported due to the different conditions of experiments.<BR>We found striking change in osmotic fragility of human red blood cells in the mixture of NaCl and saccharide solution. The sequence of hemolytic efficiency of saccharides is as follows; D-Xylose_??_L-Arabinose_??_D-Mannose_??_D-Galactose>D-Glucose>2-Deoxy-D-Glucose>[NaCl] _?? D-Ribose>D-Arabinose_??_L-Sorbose_??_L-Fucose>L-Xylose_??_ Xylitol>L-Glucose_??_D-Furctose_??_D-Sorbitol_??_D-Mannitol_??_D-Maltose_??_D-Sucrose. The effect is due to the sugar transport across the membrane, of which kinetics was shown to be a new type. The carrier is apparently a divalent carrier, or the glucose passes through the erythrocyte membrane as a dimer.
日本生物物理学会の論文