生体膜の化学興奮--濃度応答関係を中心にして

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概要

• 論文の詳細を見る

• The primary response of the typical chemically excitable membranes such as postsynaptic membranes of vertebrate end-plates is the conductance increase of the membrane. The simplest theory which can account for the three elements of a dose-conductance change curve: the maximum response, the affinity of agonist to the receptor and the cooperativity of the curve, is the two-state model. The two-state model is also compatible with the recent findings by the conductance-fluctuation analysis that the unit conductance-increase γ is independent of the kind of agonists on the cholinergic membrane.<BR>Various types of the two-state models are formulated based on the generalized twostate model of Kijima & Kijima (1978) which includes both the model of Monod, Wyman and Changeux and that of Koshland. In all types of the two-state model, Hill coefficient at the mid-point of the curve, the measure of the cooperativity, is restricted at small value when the maximum response is small.<BR>Some membranes are incompatible with the two-state models due to the above restriction and the three-state model is proposed to account for their responses. The most popular classical model, first proposed by del Castillo and Katz is essentially a kind of multi-state model which assumes the existence of more than two states of receptor-subunits to explain the cooperativity and of another 'active state' of the receptor. This model seems inadequate, however, for the full description of the rate constants of excitation process.

• 日本生物物理学会の論文

著者

• 木島 博正

  九州大学理学部生物学教室

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