T細胞抗原レセプターα/δ鎖遺伝子の漸進的再配列

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概要

• 論文の詳細を見る

• Circular DNA excised mostly by gene rearrangements was isolated from adult thymocytes and splenocytes and cloned into a bacteriophage vector. Analysis of DNA clones showed the lower frequency of T cell receptor (TCR) δ locus compared with the flanking α locus. This suggests that TCR δ locus is successively rearranged from the inside and the excision products are progressively diluted out by the following cell multiplication entailing α gene rearrangements. New V δ subfamilies, special usage of J δ 2, reciprocal joining of two D δ elements and novel sequences homologous to the human δ-gene deleting elements were also found.

• 日本生物物理学会の論文

著者

• 竹下 淳

  京都大学理学部生物物理:(現)ヘキストジャパン

• 竹下 淳

  京都大学理学部生物物理学教室

関連論文

• Novel TCR Gene Rearrangements and Expression in Radiation-induced Thymic Lymphomas1
• T細胞抗原レセプターα/δ鎖遺伝子の漸進的再配列

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