蛋白質の核酸結合様式

概要

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Up to now three different DNA binding modes have been proposed. One is the α-helix represented by the helix-turn-helix structure of prokaryotic repressors and eukaryotic homoeotic gene products. Another is the antiparallel β-sheet found in G5BP and DBP II. The other is the Zn-finger originally suggested for TF IIIA.<BR>The fourth quite new mode of DNA binding was proposed for histones H1 and H2B and then generally found in many gene reguratoly proteins. This is a repeat of β-turns composed of Ser(Thr)-Pro-X-X sequences.
日本生物物理学会の論文