RNAの構造変化によるColE1DNA複製開始の調節

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概要

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• Initiation of ColE1 plasmid replication requires hybridization of the primer transcript (RNA II) to the template DNA at the replication origin. The hybridization is inhibited by binding of another RNA, RNA I, to RNA II. This binding, which occurs in the nonessential region proximal to the 5'-end of RNA II, alters the secondary structure of RNA II even in the region far downstream of the segment where RNA I binds. Similar functional and Structural alterations of RNA II are caused by a single-base change within the nonessential region. By forming an alternative structure, the dispensable region affects folding of a downstream region, and thus participates in the regulation of DNA replication.

• 日本生物物理学会の論文

著者

• 升方 久夫

  名古屋大学理学部分子生物学教室

関連論文

• RNAの構造変化によるColE1DNA複製開始の調節

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