タンパク質膜透過のメカニズム

概要

論文の詳細を見る
The study of protein export, into or across membranes, has clearly become one of the liveliest areas in cell biology today, with rapid advances being made both in prokaryotic and eukaryotic cells. Studies of protein secretion across the membranes of the rough endoplasmic reticulum have led to the formulation of the signal hypothesis, which has stimulated many discussions and new ideas. Although bacterial cells do not contain organelles, they do have distinct compartments, such as periplasm and outer membrane. The translocation of proteins into the outer membrance and periplasmic space appeared to be amalogous to the initial step of secretion in higher organisms. The simplicity and the ease of genetic manipulability of bacteria made them the organisms of choice in the explorations of presumable universal mechanisms of protein secretion. In this review, keeping the universality in our mind, we described the successful biochemical and genetic studies of protein secretion.
日本生物物理学会の論文