神経情報の伝達とイノシトールリン脂質

概要

論文の詳細を見る
A role of inositol phospholipids in the cellular responses for the stimulations by neuromodulators and hormones was found to be very important. Inositol phospholipids are hydrolyzed immediately after the cell stimulation. The hydrolyzed products from phosphatidylinositol 4, 5-bisphosphate (PIP2), inositoltrisphosphate (IP3) and diacylglycerol, are thought to be new types of second messengers in the signal transduction systems. In the neurotransmission, however, nerve impulses transmitted synapse very fast (within 1 msec). In such a case a new type of signaling system should be considered. Gellerally speaking, it is evident that PIP2 breakdown occurs in preference to other biochemical reactions when cell receptor is stimulated. By the removal of IP3 from PIP2, a sort of distortion wave might be produced in the lipid bilayer membrane of nerve cell. Then the level of IP3 increased gradually (within about 100 msec) accompanying the elevated concentration of intracellular Ca2+, which activate various kinds of biochemical reactions successively, including protein phosphorylation, and the metabolic turnover of phosphatidylinositol. Finally, phosphoprotein will be dephosphorylated by phosphatase and the signaling system returned to the initial resting state. These process might occur in the release and reception of neurotransmitter in the synapse.
日本生物物理学会の論文