細胞性粘菌の分化パタ-ン調節のモデル

概要

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In the slug stage of cellular slime molds Dictyostelium discoideum, the prestalk cells occupy the anterior 1/4, and among the remaining posterior prespore cells there are about 10% anterior-like cells which have the same staining property as the prestalk cells. This slug differentiation pattern is well regulated independent of the slug size. Further, the pattern is basically restored if a part of the slug is excised.<BR>This survey reviews several such models that may explain the formation and the regulation capability of the differentiation pattern. The models treated are classified into the following three categories. 1) Positional information is established first, and then the differentiation follows accordingly; 2) The cytodifferentiation occurs through the balance of the labor division, and the cells sort out to form the pattern; 3) The pattern is thought to be in a dynamical equilibrium, i.e., the prestalk and the anteriorlike cells interchange incessantly while keeping the whole pattern.
日本生物物理学会の論文