Caチャンネルのゲート機構
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概要
- 論文の詳細を見る
Gating kinetics of the Ca channel have been studied recently by applying a cell attached patch clamp and a whole cell recording techniques to the rat pituitary cell line, GH<SUB>3</SUB>, and to the hair cells dissociated from a chick vestibular organ. In both preparations, Ca channels were gated open by depolarizing command pulses and were not inactivated. The activation kinetics were reasonably fitted by the mm<SUP>2</SUP> kinetic model, while the steady-state noise analysis indicated a presence of much faster opening-closing kinetics in the gating mechanism. The fast opening-closing gating mechanism was observed in the Ba cullents passing through a single Ca channel. Steady-state noise analyses and single channel Ba currents suggest a presence of dual gates in the Ca channel; the one may be a voltage dependent slow gate which operates on a reaction scheme analogous to the mm<SUP>2</SUP> process, and the other may be a less voltage dependent fast gate which seems operating independent of the slow gate.
- 日本生物物理学会の論文