生体膜を介した情報変換とポリホスホイノシチド(PPI)の役割

概要

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The polyphosphoinositides (PPI), diphosphoinositide (DPI) and triphosphoinositide (TPI), are quantitatively minor components of various eukaryotic tissues. They are of special biochemical interst because of their extraordinarily high affinity for Ca++ and the rapid turnover rate of their monoesterified phosphate groups. In addition, their metabolic turnover is accelerated with appropriate stimulations to the tissues. In this paper, we reviewed representative studies os PPI and discussed possible roles of these lipids in the stimulus-response coupling via biological membranes. Several results from the studies on the PPI in nervous tissues suggested a strong correlation between PPI and the, K+ -permeability of excitable membranes. It was also mentioned that PPI might play essential roles in ACTH-activated memory in the limbic system, ACTH-activated steroidgenesis in the adrenal cortex, ····etc. In contrast with the phosphatidylinositol (PI)-breakdown or the phospholipid-methylation that is suggested to contribute to an earlier step in the information transduction process via cellular membranes, PPI-metabolism may have important roles at a later step in the transduction process and contribute to various cellular responses.
日本生物物理学会の論文